Preheat the oven to 350°F.
Cook the macaroni in a stockpot to al dente by following the instructions on the package. Drain the water and return the macaroni to the pot.
Using a large saucepan, cook the 3 tbsp of butter and flour together over medium heat, stir continuously until smooth, allow it to bubble for one minute before mixing in milk, salt, and pepper. Continue to stir and bring the milk to a boil for 3-4 minutes or until slightly thickened. Remove from the heat and stir in the 3 shredded cheeses until smooth, followed by adding the cooked macaroni and mixing thoroughly.
Toss the panko and garlic and melted butter together.
Transfer the macaroni to a 9x7-in baking dish and sprinkle the panko mixture evenly on top. Bake for 30 to 40 minutes, uncovered, or until bubbling and the top is crispy and browned.
Remove the macaroni from the oven, sprinkle on chopped basil leaves and serve.